MolNFT v1 · #183888 · protein
Cooperation between the intrinsically disordered and ordered regions of SPT6 regulates nucleosome and pol II ctd binding, and nucleosome assembly
7O6B · Transcription elongation factor SPT6: “Cooperation between the intrinsically disordered and ordered regions of SPT6 regulates nucleosome and pol II…”. Electron microscopy, 14 pockets (best druggability 0.68). MolNFT v1 #183888 on…
- PDB
- 7O6B
- Type
- protein
- Length
- 879 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription elongation factor SPT6
- UniProt
- P23615
- Pockets
- 14 · best druggability 0.68
Structure
electron microscopy · 1 distinct chain · 53% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription elongation factor SPT6 | protein | 879 | 53% helix, 8% strand | P23615 |
Pockets
14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 475 | 0.68 | 0.79 | 48 | empty |
| 2 | 385 | 0.66 | 0.80 | 36 | empty |
| 3 | 252 | 0.57 | 0.78 | 33 | empty |
| 4 | 75 | 0.55 | 0.86 | 18 | empty |
| 5 | 183 | 0.52 | 0.78 | 25 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7O6B · Cooperation between the intrinsically disordered and ordered regions of Spt6 regulates… · the same entry in another collection · chain A against A, TM-score 1.00
- P23615 · AlphaFold monomer V2.0 prediction for transcription elongation factor SPT6 (P23615) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23615
- Elsewhere: RCSB PDB 7O6B · PDBe 7O6B · UniProt P23615
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