Research workbench
Cooperation between the intrinsically disordered and ordered regions of SPT6 regulates nucleosome and pol II ctd binding, and nucleosome assembly
Analyse Cooperation between the intrinsically disordered and ordered regions of SPT6… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7O6B
- Type
- protein
- Length
- 879 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription elongation factor SPT6
- UniProt
- P23615
- Pockets
- 14 · best druggability 0.68
Structure
electron microscopy · 1 distinct chain · 53% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription elongation factor SPT6 | protein | 879 | 53% helix, 8% strand | P23615 |
Pockets
14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 475 | 0.68 | 0.79 | 48 | empty |
| 2 | 385 | 0.66 | 0.80 | 36 | empty |
| 3 | 252 | 0.57 | 0.78 | 33 | empty |
| 4 | 75 | 0.55 | 0.86 | 18 | empty |
| 5 | 183 | 0.52 | 0.78 | 25 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7O6B · Cooperation between the intrinsically disordered and ordered regions of Spt6 regulates… · the same entry in another collection · chain A against A, TM-score 1.00
- P23615 · AlphaFold monomer V2.0 prediction for transcription elongation factor SPT6 (P23615) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23615
- Elsewhere: RCSB PDB 7O6B · PDBe 7O6B · UniProt P23615
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