MolNFT v1 · #183778 · protein

Aurora kinase a in complex with the aur-A/PDK1 inhibitor VI8

7O2V: “Aurora kinase a in complex with the aur-A/PDK1 inhibitor VI8”. X-ray diffraction, 1 ligand (V0K). MolNFT v1 #183778 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7O2V
Type: protein
Length: 264 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: O14965
Ligands: V0K

Structure

x-ray diffraction · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	264	—	O14965

Ligands and binding sites

V0K · 1-[[3,4-bis(fluoranyl)phenyl]methyl]-~{N}-[(1~{R})-2-[[(3~{E})-3-(1~{H}-imidazol-5-ylmethylidene)-2-oxidanylidene-1~{H}-indol-5-yl]amino]-2-oxidanylidene-1-phenyl-ethyl]-6-methyl-2-oxidanylidene-pyridine-3-carboxamide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7O2V · Aurora kinase a in complex with the aur-A/PDK1 inhibitor VI8 · the same entry in another collection · chain A against A, TM-score 1.00
O14965 · AlphaFold monomer V2.0 prediction for aurora kinase a (O14965) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O14965
Elsewhere: RCSB PDB 7O2V · PDBe 7O2V · UniProt O14965

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