Complex-B bound [fefe]-hydrogenase maturase hyde from T. maritima (reaction triggered in the crystal)

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 13% strand (DSSP).

Ligands and binding sites

• CPS · 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate · ligand · 2 copies · chains A
• PYR · Pyruvic acid · ligand · chains A
• 5X8 · S-adenosyl-L-cysteine · ligand · chains A
• TAM · Tris(hydroxyethyl)aminomethane · ligand · chains A
• SF4 · Iron/sulfur cluster · ligand · chains A
• FE2 · Fe (II) ion · metal · chains A
• PO4 · Phosphate ion · ion · 4 copies · chains A
• CMO · Carbon monoxide · ion · 2 copies · chains A
• CYN · Cyanide ion · ion · chains A
• CL · Chloride ion · ion · chains A
• GOL · Glycerol · additive · chains A
• EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 1 covalent, 1 modified (covalent ligand, nonstandard).

Compared structures

• 7O25 · Complex-B bound [FeFe]-hydrogenase maturase HydE from T. maritima (reaction triggered in… · the same entry in another collection · chain A against A, TM-score 1.00
• Q9X0Z6 · AlphaFold monomer V2.0 prediction for [fefe] hydrogenase maturase subunit hyde (Q9X0Z6) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9X0Z6
• Elsewhere: RCSB PDB 7O25 · PDBe 7O25 · UniProt Q9X0Z6