MolNFT v1 · #183741 · protein

Amyloid beta oligomer displayed on the alpha hemolysin scaffold

7O1Q · Alpha-hemolysin hybridized abeta: “Amyloid beta oligomer displayed on the alpha hemolysin scaffold”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #183741 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 7O1Q
Type: protein
Length: 2,051 residues
Chains: 7
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alpha-hemolysin hybridized abeta
UniProt: P09616, P05067
Pockets: 20 · best druggability 0.82

Structure

electron microscopy · 1 distinct chain · 2% helix, 59% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G	Alpha-hemolysin hybridized abeta	protein	293	2% helix, 59% strand	P09616, P05067

Pockets

20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	715	0.82	0.86	90	empty
2	501	0.82	0.88	78	empty
3	707	0.75	0.81	76	empty
4	286	0.74	0.87	52	empty
5	184	0.73	0.89	34	empty

Interfaces

14 interfaces between chains.

F–G · 2734 Å² buried · 54 hydrogen bonds · protein-protein
E–F · 2733 Å² buried · 54 hydrogen bonds · protein-protein
B–C · 2732 Å² buried · 54 hydrogen bonds · protein-protein
C–D · 2730 Å² buried · 54 hydrogen bonds · protein-protein
D–E · 2730 Å² buried · 54 hydrogen bonds · protein-protein

Compared structures

7O1Q · Amyloid beta oligomer displayed on the alpha hemolysin scaffold · the same entry in another collection · chain B against B, TM-score 1.00
P09616 · AlphaFold monomer V2.0 prediction for alpha-hemolysin (P09616) · a predicted model of the same protein · chain G against A, TM-score 0.79

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P09616
Every structure of UniProt P05067
Elsewhere: RCSB PDB 7O1Q · PDBe 7O1Q · UniProt P09616 · UniProt P05067

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.