MolNFT v1 · #183498 · protein
Human L-ALANINE:GLYOXYLATE aminotransferase minor allele variant: agxt-mi (P11L-I340M)
7NS7: “Human L-ALANINE:GLYOXYLATE aminotransferase minor allele variant: agxt-mi (P11L-I340M)”. X-ray diffraction, 5 pockets (best druggability 0.61). MolNFT v1 #183498 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7NS7
- Type
- protein
- Length
- 681 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- L-ALANINE:GLYOXYLATE aminotransferase
- EC
- 2.6.1.44, 2.6.1.51
- UniProt
- P21549
- Pockets
- 5 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | L-ALANINE:GLYOXYLATE aminotransferase (EC 2.6.1.44, 2.6.1.51) | protein | 340 | 42% helix, 13% strand | P21549 |
| B | L-ALANINE:GLYOXYLATE aminotransferase (EC 2.6.1.44, 2.6.1.51) | protein | 341 | 40% helix, 13% strand | P21549 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 297 | 0.61 | 0.79 | 33 | empty |
| 2 | 240 | 0.60 | 0.80 | 40 | empty |
| 3 | 100 | 0.40 | 0.76 | 17 | empty |
| 4 | 87 | 0.36 | 0.75 | 21 | empty |
| 5 | 57 | 0.28 | 0.74 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 3449 Ų buried · 39 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (cofactor).
Compared structures
- 7NS7 · Human L-alanine:glyoxylate aminotransferase minor allele variant: AGXT-Mi (P11L-I340M) · the same entry in another collection · chain A against A, TM-score 1.00
- P21549 · AlphaFold monomer V2.0 prediction for serine--pyruvate aminotransferase (P21549) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21549
- Elsewhere: RCSB PDB 7NS7 · PDBe 7NS7 · UniProt P21549
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