MolNFT v1 · #183489 · protein
Paired helical filament from ALZHEIMER'S disease with pet ligand apn- 1607
7NRV · Microtubule-associated protein tau: “Paired helical filament from ALZHEIMER'S disease with pet ligand apn- 1607”. Electron microscopy, 6 pockets (best druggability 0.61). MolNFT v1 #183489 on GenesisL1: 3D structure, binding sites…
- PDB
- 7NRV
- Type
- protein
- Length
- 770 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Microtubule-associated protein tau
- UniProt
- P10636
- Pockets
- 6 · best druggability 0.61
Structure
electron microscopy · 1 distinct chain · 0% helix, 57% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, F, B, C, D, E, G, H, I, J | Microtubule-associated protein tau | protein | 77 | 0% helix, 57% strand | P10636 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 60 | 0.61 | 0.92 | 25 | empty |
| 2 | 54 | 0.61 | 0.93 | 25 | empty |
| 3 | 108 | 0.38 | 0.75 | 20 | empty |
| 4 | 63 | 0.30 | 0.74 | 19 | empty |
| 5 | 60 | 0.29 | 0.74 | 21 | empty |
Interfaces
24 interfaces between chains.
- F–J · 3233 Ų buried · 99 hydrogen bonds · protein-protein
- H–J · 3231 Ų buried · 92 hydrogen bonds · protein-protein
- C–E · 3224 Ų buried · 92 hydrogen bonds · protein-protein
- A–D · 3220 Ų buried · 104 hydrogen bonds · protein-protein
- F–E · 3216 Ų buried · 92 hydrogen bonds · protein-protein
Compared structures
- 7NRV · Paired helical filament from Alzheimer's disease with PET ligand APN-1607 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10636
- Elsewhere: RCSB PDB 7NRV · PDBe 7NRV · UniProt P10636
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