MolNFT v1 · #183424 · protein
Camp-bound rabbit HCN4 stabilized in lmng-chs detergent mixture
7NP4 · POTASSIUM/SODIUM hyperpolarization-activated cyclic…: “Camp-bound rabbit HCN4 stabilized in lmng-chs detergent mixture”. Electron microscopy, 1 ligand (CMP), 20 pockets (best druggability 0.82). MolNFT v1 #183424 on GenesisL1: 3D…
- PDB
- 7NP4
- Type
- protein
- Length
- 2,004 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- POTASSIUM/SODIUM hyperpolarization-activated cyclic nucleotide-gated channel…
- UniProt
- Q9TV66
- Ligands
- CMP
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 1 distinct chain · 62% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | POTASSIUM/SODIUM hyperpolarization-activated cyclic nucleotide-gated channel 4,POTASSIUM/SODIUM hyperpolarization- activated cyclic nucleotide-gated channel 4 | protein | 501 | 62% helix, 9% strand | Q9TV66 |
Ligands and binding sites
- CMP · Adenosine-3',5'-cyclic-monophosphate · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 883 | 0.82 | 0.84 | 86 | empty |
| 2 | 1150 | 0.82 | 0.83 | 89 | empty |
| 3 | 1138 | 0.81 | 0.83 | 89 | empty |
| 4 | 228 | 0.81 | 0.94 | 56 | empty |
| 5 | 946 | 0.80 | 0.82 | 80 | empty |
Interfaces
6 interfaces between chains.
- A–B · 3023 Ų buried · 16 hydrogen bonds · protein-protein
- C–D · 2991 Ų buried · 15 hydrogen bonds · protein-protein
- A–D · 2987 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 2980 Ų buried · 15 hydrogen bonds · protein-protein
- B–D · 383 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 7NP4 · cAMP-bound rabbit HCN4 stabilized in LMNG-CHS detergent mixture · the same entry in another collection · chain D against D, TM-score 1.00
- Q9TV66 · AlphaFold monomer V2.0 prediction for POTASSIUM/SODIUM hyperpolarization-activated cyclic… · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9TV66
- Elsewhere: RCSB PDB 7NP4 · PDBe 7NP4 · UniProt Q9TV66
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