MolNFT v1 · #183423 · protein
Camp-free rabbit HCN4 stabilized in lmng-chs detergent mixture
7NP3 · POTASSIUM/SODIUM hyperpolarization-activated cyclic…: “Camp-free rabbit HCN4 stabilized in lmng-chs detergent mixture”. Electron microscopy, 20 pockets (best druggability 0.87). MolNFT v1 #183423 on GenesisL1: 3D structure, binding…
- PDB
- 7NP3
- Type
- protein
- Length
- 1,960 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- POTASSIUM/SODIUM hyperpolarization-activated cyclic nucleotide-gated channel…
- UniProt
- Q9TV66
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 1 distinct chain · 62% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | POTASSIUM/SODIUM hyperpolarization-activated cyclic nucleotide-gated channel 4,POTASSIUM/SODIUM hyperpolarization- activated cyclic nucleotide-gated channel 4 | protein | 490 | 62% helix, 5% strand | Q9TV66 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 776 | 0.87 | 0.90 | 56 | empty |
| 2 | 400 | 0.73 | 0.83 | 48 | empty |
| 3 | 445 | 0.72 | 0.82 | 47 | empty |
| 4 | 503 | 0.69 | 0.79 | 54 | empty |
| 5 | 487 | 0.69 | 0.79 | 52 | empty |
Interfaces
6 interfaces between chains.
- B–C · 2739 Ų buried · 21 hydrogen bonds · protein-protein
- A–D · 2736 Ų buried · 21 hydrogen bonds · protein-protein
- A–B · 2735 Ų buried · 22 hydrogen bonds · protein-protein
- C–D · 2735 Ų buried · 21 hydrogen bonds · protein-protein
- A–C · 151 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 7NP3 · cAMP-free rabbit HCN4 stabilized in LMNG-CHS detergent mixture · the same entry in another collection · chain D against D, TM-score 1.00
- Q9TV66 · AlphaFold monomer V2.0 prediction for POTASSIUM/SODIUM hyperpolarization-activated cyclic… · a predicted model of the same protein · chain C against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9TV66
- Elsewhere: RCSB PDB 7NP3 · PDBe 7NP3 · UniProt Q9TV66
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