MolNFT v1 · #183378 · protein
Cryo-EM structure of the folate-specific ecf transporter complex in MSP2N2 lipid nanodiscs
7NNU · Energy-coupling factor transporter ATP-binding protein ECFA1: “Cryo-EM structure of the folate-specific ecf transporter complex in MSP2N2 lipid nanodiscs”. Electron microscopy, 9 pockets (best druggability 0.82). MolNFT v1 #183378…
- PDB
- 7NNU
- Type
- protein
- Length
- 982 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Energy-coupling factor transporter ATP-binding protein ECFA1; Energy-coupling factor…
- EC
- 7.-.-.-, 3.6.3.-
- UniProt
- Q1GBJ0, Q1GBI9, Q1G929, Q1GBI8
- Pockets
- 9 · best druggability 0.82
Structure
electron microscopy · 4 distinct chains · 55% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Energy-coupling factor transporter ATP-binding protein ECFA1 (EC 7.-.-.-) | protein | 279 | 41% helix, 20% strand | Q1GBJ0 |
| B | Energy-coupling factor transporter ATP-binding protein ECFA2 (EC 3.6.3.-) | protein | 273 | 42% helix, 21% strand | Q1GBI9 |
| C | Conserved hypothetical membrane protein | protein | 169 | 75% helix, 2% strand | Q1G929 |
| D | Energy-coupling factor transporter transmembrane protein ecft | protein | 261 | 72% helix, 1% strand | Q1GBI8 |
Pockets
9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1171 | 0.82 | 0.84 | 117 | empty |
| 2 | 871 | 0.78 | 0.81 | 50 | empty |
| 3 | 507 | 0.73 | 0.82 | 62 | empty |
| 4 | 247 | 0.56 | 0.77 | 31 | empty |
| 5 | 259 | 0.53 | 0.76 | 35 | empty |
Interfaces
6 interfaces between chains.
- C–D · 2923 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 1473 Ų buried · 23 hydrogen bonds · protein-protein
- A–B · 1165 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 788 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 299 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 7NNU · Cryo-EM structure of the folate-specific ECF transporter complex in MSP2N2 lipid nanodiscs · the same entry in another collection · chain A against A, TM-score 1.00
- Q1GBI9 · AlphaFold monomer V2.0 prediction for energy-coupling factor transporter ATP-binding… · a predicted model of the same protein · chain B against A, TM-score 0.98
- Q1GBJ0 · AlphaFold monomer V2.0 prediction for energy-coupling factor transporter ATP-binding… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q1GBJ0
- Every structure of UniProt Q1GBI9
- Every structure of UniProt Q1G929
- Every structure of UniProt Q1GBI8
- Elsewhere: RCSB PDB 7NNU · PDBe 7NNU · UniProt Q1GBJ0 · UniProt Q1GBI9 · UniProt Q1G929 · UniProt Q1GBI8
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