MolNFT v1 · #183347 · protein

Rabbit HCN4 stabilised in amphipol A8-35

7NMN · POTASSIUM/SODIUM hyperpolarization-activated cyclic…: “Rabbit HCN4 stabilised in amphipol A8-35”. Electron microscopy, 20 pockets (best druggability 0.87). MolNFT v1 #183347 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 7NMN
Type: protein
Length: 1,876 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: POTASSIUM/SODIUM hyperpolarization-activated cyclic nucleotide-gated channel 4,RABBIT HCN4
UniProt: Q9TV66
Pockets: 20 · best druggability 0.87

Structure

electron microscopy · 1 distinct chain · 62% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	POTASSIUM/SODIUM hyperpolarization-activated cyclic nucleotide-gated channel 4,RABBIT HCN4	protein	469	62% helix, 8% strand	Q9TV66

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	837	0.87	0.89	55	empty
2	804	0.72	0.77	65	empty
3	758	0.72	0.78	61	empty
4	64	0.67	0.95	17	empty
5	61	0.67	0.95	18	empty

Interfaces

6 interfaces between chains.

A–D · 3183 Å² buried · 28 hydrogen bonds · protein-protein
C–D · 3180 Å² buried · 27 hydrogen bonds · protein-protein
B–C · 3179 Å² buried · 29 hydrogen bonds · protein-protein
A–B · 3177 Å² buried · 28 hydrogen bonds · protein-protein
A–C · 153 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

7NMN · Rabbit HCN4 stabilised in amphipol A8-35 · the same entry in another collection · chain D against D, TM-score 1.00
Q9TV66 · AlphaFold monomer V2.0 prediction for POTASSIUM/SODIUM hyperpolarization-activated cyclic… · a predicted model of the same protein · chain C against A, TM-score 0.84

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9TV66
Elsewhere: RCSB PDB 7NMN · PDBe 7NMN · UniProt Q9TV66

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