MolNFT v1 · #183025 · protein

Type 3 alpha-synuclein filament seeded in vitro by filaments purified from multiple systems atrophy case 5

7NCK: “Type 3 alpha-synuclein filament seeded in vitro by filaments purified from multiple systems atrophy case 5”. Electron microscopy, 2 pockets (best druggability 0.73). MolNFT v1 #183025 on GenesisL1: 3D structure, binding sites and…

PDB: 7NCK
Type: protein
Length: 384 residues
Chains: 6
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alpha-synuclein
UniProt: P37840
Pockets: 2 · best druggability 0.73

Structure

electron microscopy · 1 distinct chain · 0% helix, 69% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A, C, D, E, F	Alpha-synuclein	protein	64	0% helix, 69% strand	P37840

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	161	0.73	0.91	44	empty
2	111	0.37	0.74	29	empty

Interfaces

5 interfaces between chains.

E–F · 2460 Å² buried · 70 hydrogen bonds · protein-protein
C–F · 2455 Å² buried · 73 hydrogen bonds · protein-protein
B–D · 2452 Å² buried · 70 hydrogen bonds · protein-protein
C–D · 2446 Å² buried · 74 hydrogen bonds · protein-protein
B–A · 2416 Å² buried · 69 hydrogen bonds · protein-protein

Compared structures

7NCK · Type 3 alpha-synuclein filament seeded in vitro by filaments purified from Multiple… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37840
Elsewhere: RCSB PDB 7NCK · PDBe 7NCK · UniProt P37840

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.