MolNFT v1 · #183021 · protein
Type 2A alpha-synuclein filament seeded in vitro by filaments purified from multiple systems atrophy case 2
7NCG: “Type 2A alpha-synuclein filament seeded in vitro by filaments purified from multiple systems atrophy case 2”. Electron microscopy, 6 pockets (best druggability 0.80). MolNFT v1 #183021 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7NCG
- Type
- protein
- Length
- 732 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-synuclein
- UniProt
- P37840
- Pockets
- 6 · best druggability 0.80
Structure
electron microscopy · 1 distinct chain · 0% helix, 70% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L | Alpha-synuclein | protein | 61 | 0% helix, 70% strand | P37840 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 562 | 0.80 | 0.86 | 77 | empty |
| 2 | 534 | 0.79 | 0.86 | 76 | empty |
| 3 | 167 | 0.57 | 0.82 | 24 | empty |
| 4 | 70 | 0.32 | 0.75 | 24 | empty |
| 5 | 58 | 0.30 | 0.75 | 20 | empty |
Interfaces
31 interfaces between chains.
- F–K · 2458 Ų buried · 61 hydrogen bonds · protein-protein
- D–H · 2453 Ų buried · 61 hydrogen bonds · protein-protein
- B–D · 2451 Ų buried · 59 hydrogen bonds · protein-protein
- A–F · 2442 Ų buried · 59 hydrogen bonds · protein-protein
- B–C · 2436 Ų buried · 60 hydrogen bonds · protein-protein
Compared structures
- 7NCG · Type 2A alpha-synuclein filament seeded in vitro by filaments purified from Multiple… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37840
- Elsewhere: RCSB PDB 7NCG · PDBe 7NCG · UniProt P37840
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