MolNFT v1 · #183017 · protein

Crystal structure of fructose-bisphosphate aldolase fbap from bacillus methanolicus

7NCC · Putative class II fructose-1,6-bisphosphate aldolase: “Crystal structure of fructose-bisphosphate aldolase fbap from bacillus methanolicus”. X-ray diffraction, 2 ligands (MLT, PO4), 2 pockets (best druggability 0.48). MolNFT v1…

PDB: 7NCC
Type: protein
Length: 568 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative class II fructose-1,6-bisphosphate aldolase
UniProt: Q6TV43
Ligands: MLT, PO4
Pockets: 2 · best druggability 0.48

Structure

x-ray diffraction · 1 distinct chain · 51% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Putative class II fructose-1,6-bisphosphate aldolase	protein	284	51% helix, 15% strand	Q6TV43

Ligands and binding sites

MLT · D-malate · ligand · chains A
PO4 · Phosphate ion · ion · 6 copies · chains A, B
IMD · Imidazole · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	112	0.48	0.80	25	PO4
2	110	0.43	0.78	22	PO4

Interfaces

1 interface between chains.

A–B · 1650 Å² buried · 32 hydrogen bonds · protein-protein

Compared structures

7NCC · Crystal structure of fructose-bisphosphate aldolase FBAP from Bacillus methanolicus · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6TV43
Elsewhere: RCSB PDB 7NCC · PDBe 7NCC · UniProt Q6TV43

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