MolNFT v1 · #183005 · protein
The structure of the humanised A33 Fab C226S variant, an immunotherapy candidate for colorectal cancer
7NC0 · A33 Fab light chain: “The structure of the humanised A33 Fab C226S variant, an immunotherapy candidate for colorectal cancer”. X-ray diffraction, 3 pockets (best druggability 0.51). MolNFT v1 #183005 on GenesisL1: 3D structure…
- PDB
- 7NC0
- Type
- protein
- Length
- 426 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- A33 Fab light chain; A33 Fab heavy chain
- Pockets
- 3 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | A33 Fab light chain | protein | 213 | 5% helix, 51% strand | — |
| H | A33 Fab heavy chain | protein | 213 | 9% helix, 48% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 326 | 0.51 | 0.73 | 49 | empty |
| 2 | 136 | 0.39 | 0.73 | 28 | empty |
| 3 | 107 | 0.36 | 0.74 | 25 | empty |
Interfaces
1 interface between chains.
- L–H · 1692 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 7NC0 · The structure of the humanised A33 Fab C226S variant, an immunotherapy candidate for… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7NC0 · PDBe 7NC0
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