Research workbench
The structure of the humanised A33 Fab C226S variant, an immunotherapy candidate for colorectal cancer
Analyse The structure of the humanised A33 Fab C226S variant, an immunotherapy… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7NC0
- Type
- protein
- Length
- 426 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- A33 Fab light chain; A33 Fab heavy chain
- Pockets
- 3 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | A33 Fab light chain | protein | 213 | 5% helix, 51% strand | — |
| H | A33 Fab heavy chain | protein | 213 | 9% helix, 48% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 326 | 0.51 | 0.73 | 49 | empty |
| 2 | 136 | 0.39 | 0.73 | 28 | empty |
| 3 | 107 | 0.36 | 0.74 | 25 | empty |
Interfaces
1 interface between chains.
- L–H · 1692 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 7NC0 · The structure of the humanised A33 Fab C226S variant, an immunotherapy candidate for… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7NC0 · PDBe 7NC0
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