MolNFT v1 · #182954 · protein
Full-length tcdb and CSPG4 (401-560) complex
7N9Y · Chondroitin sulfate proteoglycan 4: “Full-length tcdb and CSPG4 (401-560) complex”. Electron microscopy, 20 pockets (best druggability 0.66). MolNFT v1 #182954 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7N9Y
- Type
- protein
- Length
- 2,505 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chondroitin sulfate proteoglycan 4; Toxin B
- EC
- 3.4.22.-
- UniProt
- Q6UVK1, P18177
- Pockets
- 20 · best druggability 0.66
Structure
electron microscopy · 2 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Chondroitin sulfate proteoglycan 4 | protein | 140 | 0% helix, 0% strand | Q6UVK1 |
| A | Toxin B (EC 3.4.22.-) | protein | 2365 | 0% helix, 0% strand | P18177 |
Pockets
20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 616 | 0.66 | 0.76 | 109 | empty |
| 2 | 717 | 0.62 | 0.72 | 106 | empty |
| 3 | 633 | 0.62 | 0.73 | 84 | empty |
| 4 | 470 | 0.57 | 0.73 | 75 | empty |
| 5 | 439 | 0.55 | 0.72 | 73 | empty |
Interfaces
1 interface between chains.
- B–A · 82 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6UVK1
- Every structure of UniProt P18177
- Elsewhere: RCSB PDB 7N9Y · PDBe 7N9Y · UniProt Q6UVK1 · UniProt P18177
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