MolNFT v1 · #182867 · protein

Crystal structure of PI5P4KIIALPHA

7N6Z · Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha: “Crystal structure of PI5P4KIIALPHA”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.66). MolNFT v1 #182867 on GenesisL1: 3D structure, binding sites and…

PDB: 7N6Z
Type: protein
Length: 312 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
EC: 2.7.1.149
UniProt: P48426
Ligands: SO4
Pockets: 2 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149)	protein	312	38% helix, 22% strand	P48426

Ligands and binding sites

SO4 · Sulfate ion · ion · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	423	0.66	0.78	43	empty
2	95	0.38	0.76	21	empty

Compared structures

7N6Z · Crystal Structure of PI5P4KIIAlpha · the same entry in another collection · chain A against A, TM-score 1.00
P48426 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 5-phosphate 4-kinase type-2… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P48426
Elsewhere: RCSB PDB 7N6Z · PDBe 7N6Z · UniProt P48426

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