UniProt P48426
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (P48426)
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (UniProt P48426), EC 2.7.1.149: 23 experimental structures on GenesisL1, 14 ligands bound, 26 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P48426
- Protein
- Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
- EC
- 2.7.1.149
- Experimental structures
- 23
- Predicted models
- 0
- Ligands
- 14
- Pockets
- 26 · 7 records with a druggable one
Structures
23 records of P48426 in the MolNFT archive: 23 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2YBX | Crystal Structure of Human Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha | x-ray diffraction | A, B | — | — |
| 2YBX | Crystal structure of human phosphatidylinositol-5-phosphate 4-kinase type-2 alpha | x-ray diffraction | A, B | — | — |
| 6OSP | Crystal Structure Analysis of PIP4K2A | x-ray diffraction | A, B | N51 | 6 (best 0.68) |
| 6OSP | Crystal structure analysis of PIP4K2A | x-ray diffraction | A, B | N51 | — |
| 6UX9 | Crystal Structure Analysis of PIP4K2A | x-ray diffraction | A, B | UHJ | 10 (best 0.68) |
| 6UX9 | Crystal structure analysis of PIP4K2A | x-ray diffraction | A, B | UHJ | — |
| 6YM3 | Crystal structure of compound 1 with PIP4K2A | x-ray diffraction | A, B | OYZ, PO4 | — |
| 6YM4 | Crystal structure of bay-297 with PIP4K2A | x-ray diffraction | A, B | P4Z | — |
| 6YM5 | Crystal structure of bay-091 with PIP4K2A | x-ray diffraction | A, B | PO4, OZ5 | — |
| 7N6Z | Crystal structure of PI5P4KIIALPHA | x-ray diffraction | A | SO4 | — |
| 7N71 | Crystal Structure of PI5P4KIIAlpha | x-ray diffraction | A | SO4 | 2 (best 0.66) |
| 7N71 | Crystal structure of PI5P4KIIALPHA | x-ray diffraction | A | SO4 | — |
| 7N7J | Crystal structure of PI5P4KIIALPHA complex with amppnp | x-ray diffraction | A | MN, ANP, SO4 | — |
| 7N7K | Crystal structure of PI5P4KIIALPHA complex with amppnp | x-ray diffraction | A | MN, ANP, SO4 | — |
| 7N7L | Crystal structure of PI5P4KIIALPHA complex with bi-D1870 | x-ray diffraction | A | 584, SO4 | — |
| 7N7M | Crystal Structure of PI5P4KIIAlpha complex with BI-2536 | x-ray diffraction | A | R78, SO4 | 2 (best 0.65) |
| 7N7M | Crystal structure of PI5P4KIIALPHA complex with bi-2536 | x-ray diffraction | A | R78, SO4 | — |
| 7N7N | Crystal Structure of PI5P4KIIAlpha complex with Volasertib | x-ray diffraction | A | IBI, SO4 | 2 (best 0.66) |
| 7N7N | Crystal structure of PI5P4KIIALPHA complex with volasertib | x-ray diffraction | A | IBI, SO4 | — |
| 7N7O | Crystal Structure of PI5P4KIIAlpha complex with Palbociclib | x-ray diffraction | A | LQQ, SO4 | 2 (best 0.64) |
| 7N7O | Crystal structure of PI5P4KIIALPHA complex with palbociclib | x-ray diffraction | A | LQQ, SO4 | — |
| 8C8C | Crystal Structure of Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PI5P4Ka) bound to an… | x-ray diffraction | A | U1U | 2 (best 0.71) |
| P48426 | AlphaFold monomer V2.0 prediction for phosphatidylinositol 5-phosphate 4-kinase type-2 alpha… | — | — | — |
Ligands
- SO4 · Sulfate ion · in 12 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 2 records
- IBI · N-{trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}-4-{[(7R)-7-ethyl-5-methyl-8-(1-methylethyl)-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxybenzamide · in 2 records
- LQQ · 6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7(8H)-one · in 2 records
- MN · Manganese (II) ion · in 2 records
- N51 · 4-{[(2E)-4-(dimethylamino)but-2-enoyl]amino}-N-(3-{[6-(1H-indol-3-yl)pyrimidin-4-yl]amino}phenyl)benzamide · in 2 records
- PO4 · Phosphate ion · in 2 records
- R78 · 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide · in 2 records
- UHJ · N-[4-(5-{(Z)-[(2E)-2-imino-4-oxo-1,3-thiazolidin-5-ylidene]methyl}pyridin-3-yl)phenyl]methanesulfonamide · in 2 records
- 584 · (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one · in 1 record
- OYZ · (2~{R})-2-[[3-cyano-2-[4-(2-ethoxyphenyl)phenyl]-5,8-dihydro-1,7-naphthyridin-4-yl]amino]propanoic acid · in 1 record
- OZ5 · (2~{R})-2-[[3-cyano-2-[4-(2-fluoranyl-3-methyl-phenyl) phenyl]-1,7-naphthyridin-4-yl]amino]butanoic acid · in 1 record
- P4Z · (2~{R})-2-[[2-[4-(3-chloranyl-2-fluoranyl-phenyl) phenyl]-3-cyano-1,7-naphthyridin-4-yl]amino]butanamide · in 1 record
- U1U · ~{N}-(3-chloranyl-4-methoxy-phenyl)-7-(3,4-dimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine · in 1 record
Elsewhere
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