MolNFT v1 · #18276 · protein
Mouse importin alpha-bipartite nls N1N2 from xenopus laevis phosphoprotein complex
1PJN · Histone-binding protein N1/N2: “Mouse importin alpha-bipartite nls N1N2 from xenopus laevis phosphoprotein complex”. X-ray diffraction, 1 pocket (best druggability 0.48). MolNFT v1 #18276 on GenesisL1: 3D structure, binding sites…
- PDB
- 1PJN
- Type
- protein
- Length
- 447 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone-binding protein N1/N2; Importin alpha-2 subunit
- UniProt
- P52293, P06180
- Pockets
- 1 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone-binding protein N1/N2 | protein | 21 | 0% helix, 0% strand | P52293 |
| B | Importin alpha-2 subunit | protein | 426 | 73% helix, 0% strand | P06180 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 65 | 0.48 | 0.84 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1442 Ų buried · 33 hydrogen bonds · protein-protein
Compared structures
- 1PJN · Mouse Importin alpha-bipartite NLS N1N2 from Xenopus laevis phosphoprotein Complex · the same entry in another collection · chain A against A, TM-score 1.00
- P06180 · AlphaFold monomer V2.0 prediction for histone-binding protein N1/N2 (P06180) · a predicted model of the same protein · chain B against A, TM-score 0.35
- P52293 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52293) · a predicted model of the same protein · chain A against A, TM-score 0.16
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52293
- Every structure of UniProt P06180
- Elsewhere: RCSB PDB 1PJN · PDBe 1PJN · UniProt P52293 · UniProt P06180
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.