MolNFT v1 · #18273 · protein
Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit
1PJK · Casein kinase II, alpha chain: “Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit”. X-ray diffraction, 2 ligands (ANP, CL), 2 pockets (best druggability 0.64). MolNFT v1 #18273 on…
- PDB
- 1PJK
- Type
- protein
- Length
- 331 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Casein kinase II, alpha chain
- EC
- 2.7.1.37
- UniProt
- P68400
- Ligands
- ANP, CL
- Pockets
- 2 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Casein kinase II, alpha chain (EC 2.7.1.37) | protein | 331 | 40% helix, 15% strand | P68400 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 373 | 0.64 | 0.78 | 44 | ANP |
| 2 | 53 | 0.32 | 0.77 | 15 | empty |
Compared structures
- 1PJK · Crystal Structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic… · the same entry in another collection · chain A against A, TM-score 1.00
- P68400 · AlphaFold monomer V2.0 prediction for casein kinase II subunit alpha (P68400) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P68400
- Elsewhere: RCSB PDB 1PJK · PDBe 1PJK · UniProt P68400
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