MolNFT v1 · #182658 · protein
Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 673-986
7MZY · ALK tyrosine kinase receptor: “Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 673-986”. X-ray diffraction, 4 pockets (best druggability 0.61). MolNFT v1 #182658 on GenesisL1: 3D structure, binding…
- PDB
- 7MZY
- Type
- protein
- Length
- 609 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ALK tyrosine kinase receptor
- EC
- 2.7.10.1
- UniProt
- Q9UM73
- Pockets
- 4 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 12% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ALK tyrosine kinase receptor (EC 2.7.10.1) | protein | 307 | 11% helix, 22% strand | Q9UM73 |
| B | ALK tyrosine kinase receptor (EC 2.7.10.1) | protein | 302 | 12% helix, 23% strand | Q9UM73 |
Ligands and binding sites
- ACT · Acetate ion · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 122 | 0.61 | 0.86 | 32 | empty |
| 2 | 253 | 0.59 | 0.79 | 41 | empty |
| 3 | 83 | 0.30 | 0.72 | 14 | empty |
| 4 | 52 | 0.25 | 0.74 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 785 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 7MZY · Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 673-986 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UM73 · AlphaFold monomer V2.0 prediction for ALK tyrosine kinase receptor (Q9UM73) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UM73
- Elsewhere: RCSB PDB 7MZY · PDBe 7MZY · UniProt Q9UM73
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