MolNFT v1 · #182656 · protein
Anaplastic lymphoma kinase (ALK) extracellular ligand binding region 673-1025
7MZW · ALK tyrosine kinase receptor: “Anaplastic lymphoma kinase (ALK) extracellular ligand binding region 673-1025”. Solution nmr, 1 pocket (best druggability 0.33). MolNFT v1 #182656 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 7MZW
- Type
- protein
- Length
- 353 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ALK tyrosine kinase receptor
- EC
- 2.7.10.1
- UniProt
- Q9UM73
- Pockets
- 1 · best druggability 0.33
Structure
solution nmr · 1 distinct chain · 10% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ALK tyrosine kinase receptor (EC 2.7.10.1) | protein | 353 | 10% helix, 25% strand | Q9UM73 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 86 | 0.33 | 0.74 | 17 | empty |
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 7MZW · Anaplastic lymphoma kinase (ALK) extracellular ligand binding region 673-1025 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UM73 · AlphaFold monomer V2.0 prediction for ALK tyrosine kinase receptor (Q9UM73) · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UM73
- Elsewhere: RCSB PDB 7MZW · PDBe 7MZW · UniProt Q9UM73
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