MolNFT v1 · #182615 · protein
Cryo-EM structure of P110ALPHA in complex with P85ALPHA
7MYN · Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic…: “Cryo-EM structure of P110ALPHA in complex with P85ALPHA”. Electron microscopy, 18 pockets (best druggability 0.87). MolNFT v1 #182615 on GenesisL1: 3D structure, binding…
- PDB
- 7MYN
- Type
- protein
- Length
- 1,253 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform…
- EC
- 2.7.1.153, 2.7.11.1
- UniProt
- P42336, P27986
- Pockets
- 18 · best druggability 0.87
Structure
electron microscopy · 2 distinct chains · 45% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153, 2.7.11.1) | protein | 977 | 40% helix, 17% strand | P42336 |
| B | Phosphatidylinositol 3-kinase regulatory subunit alpha | protein | 276 | 63% helix, 8% strand | P27986 |
Pockets
18 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1060 | 0.87 | 0.88 | 113 | empty |
| 2 | 1188 | 0.83 | 0.84 | 85 | empty |
| 3 | 542 | 0.78 | 0.85 | 57 | empty |
| 4 | 399 | 0.69 | 0.81 | 44 | empty |
| 5 | 229 | 0.67 | 0.84 | 44 | empty |
Interfaces
1 interface between chains.
- A–B · 3241 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
- 7MYN · Cryo-EM Structure of p110alpha in complex with p85alpha · the same entry in another collection · chain A against A, TM-score 1.00
- P42336 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 4,5-bisphosphate 3-kinase… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42336
- Every structure of UniProt P27986
- Elsewhere: RCSB PDB 7MYN · PDBe 7MYN · UniProt P42336 · UniProt P27986
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