MolNFT v1 · #182559 · protein + DNA
Crystal structure of BAZ2A with DNA
7MWH · Bromodomain adjacent to zinc finger domain protein 2A: “Crystal structure of BAZ2A with DNA”. X-ray diffraction, 1 ligand (UNX), 3 pockets (best druggability 0.69). MolNFT v1 #182559 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7MWH
- Type
- protein + DNA
- Length
- 238 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bromodomain adjacent to zinc finger domain protein 2A; DNA…
- UniProt
- Q9UIF9
- Ligands
- UNX
- Pockets
- 3 · best druggability 0.69
Structure
x-ray diffraction · 3 distinct chains · 27% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Bromodomain adjacent to zinc finger domain protein 2A | protein | 107 | 27% helix, 30% strand | Q9UIF9 |
| C | DNA (5'-D(*CP*GP*GP*AP*AP*TP*GP*TP*AP*GP*GP*C)-3') | dna | 12 | — | — |
| D | DNA (5'-D(*GP*CP*CP*TP*AP*(5CM)P*AP*TP*TP*CP*CP*G)-3') | dna | 12 | — | — |
Ligands and binding sites
- UNX · Unknown atom or ion · ion · 12 copies · chains A, B, D, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 720 | 0.69 | 0.77 | 48 | UNX |
| 2 | 171 | 0.54 | 0.80 | 22 | empty |
| 3 | 132 | 0.53 | 0.81 | 22 | empty |
Interfaces
6 interfaces between chains.
- A–B · 796 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 544 Ų buried · 55 hydrogen bonds · nucleic-nucleic
- B–C · 132 Ų buried · 1 hydrogen bond · protein-nucleic
- A–D · 78 Ų buried · 0 hydrogen bonds · protein-nucleic
- A–C · 64 Ų buried · 0 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 1 modified (nucleotide modification).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UIF9
- Elsewhere: RCSB PDB 7MWH · PDBe 7MWH · UniProt Q9UIF9
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