MolNFT v1 · #182544 · protein
Crystal structure of the homo sapiens NUP93-NUP53 complex (NUP93 residues 174-819; NUP53 residues 84-150)
7MW1 · Nuclear pore complex protein NUP93: “Crystal structure of the homo sapiens NUP93-NUP53 complex (NUP93 residues 174-819; NUP53 residues 84-150)”. X-ray diffraction, 15 pockets (best druggability 0.66). MolNFT v1 #182544 on GenesisL1…
- PDB
- 7MW1
- Type
- protein
- Length
- 1,258 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclear pore complex protein NUP93; Nucleoporin NUP35
- UniProt
- Q8N1F7, Q8NFH5
- Pockets
- 15 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 65% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Nuclear pore complex protein NUP93 | protein | 621 | 66% helix, 3% strand | Q8N1F7 |
| D, C | Nucleoporin NUP35 | protein | 8 | 0% helix, 13% strand | Q8NFH5 |
Pockets
15 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 742 | 0.66 | 0.75 | 49 | empty |
| 2 | 52 | 0.57 | 0.91 | 19 | empty |
| 3 | 424 | 0.57 | 0.74 | 60 | empty |
| 4 | 223 | 0.55 | 0.78 | 24 | empty |
| 5 | 224 | 0.55 | 0.78 | 25 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1021 Ų buried · 9 hydrogen bonds · protein-protein
- B–D · 585 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 566 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 7MW1 · Crystal structure of the Homo sapiens NUP93-NUP53 complex (NUP93 residues 174-819; NUP53… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8N1F7 · AlphaFold monomer V2.0 prediction for nuclear pore complex protein NUP93 (Q8N1F7) · a predicted model of the same protein · chain A against A, TM-score 0.91
- Q8NFH5 · AlphaFold monomer V2.0 prediction for nucleoporin NUP35 (Q8NFH5) · a predicted model of the same protein · chain D against A, TM-score 0.64
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8N1F7
- Every structure of UniProt Q8NFH5
- Elsewhere: RCSB PDB 7MW1 · PDBe 7MW1 · UniProt Q8N1F7 · UniProt Q8NFH5
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