MolNFT v1 · #182542 · protein
Single particle cryo-EM structure of the chaetomium thermophilum NUP188-NIC96-NUP145N complex (NUP188 residues 1-1858; NIC96 residues 240-301; NUP145N residues 640-732)
7MVZ · Nucleoporin NUP188: “Single particle cryo-EM structure of the chaetomium thermophilum NUP188-NIC96-NUP145N complex (NUP188…”. Electron microscopy, 20 pockets (best druggability 0.83). MolNFT v1 #182542 on GenesisL1: 3D structure…
- PDB
- 7MVZ
- Type
- protein
- Length
- 1,707 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoporin NUP188; Nucleoporin NIC96; Nucleoporin NUP145N
- UniProt
- G0SFH5, G0S024, G0SAK3
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 3 distinct chains · 66% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleoporin NUP188 | protein | 1641 | 66% helix, 1% strand | G0SFH5 |
| B | Nucleoporin NIC96 | protein | 53 | 85% helix, 0% strand | G0S024 |
| C | Nucleoporin NUP145N | protein | 13 | 0% helix, 0% strand | G0SAK3 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1114 | 0.83 | 0.84 | 114 | empty |
| 2 | 1024 | 0.83 | 0.84 | 104 | empty |
| 3 | 273 | 0.82 | 0.92 | 40 | empty |
| 4 | 798 | 0.73 | 0.78 | 86 | empty |
| 5 | 556 | 0.71 | 0.80 | 59 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1980 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 495 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7MVZ · Single particle cryo-EM structure of the Chaetomium thermophilum Nup188-Nic96-Nup145N… · the same entry in another collection · chain A against A, TM-score 1.00
- G0SFH5 · AlphaFold monomer V2.0 prediction for nucleoporin NUP188 (G0SFH5) · a predicted model of the same protein · chain A against A, TM-score 0.97
- G0S024 · AlphaFold monomer V2.0 prediction for nucleoporin NIC96 (G0S024) · a predicted model of the same protein · chain B against A, TM-score 0.62
- G0SAK3 · AlphaFold monomer V2.0 prediction for nucleoporin NUP145 (G0SAK3) · a predicted model of the same protein · chain C against A, TM-score 0.30
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0SFH5
- Every structure of UniProt G0S024
- Every structure of UniProt G0SAK3
- Elsewhere: RCSB PDB 7MVZ · PDBe 7MVZ · UniProt G0SFH5 · UniProt G0S024 · UniProt G0SAK3
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