MolNFT v1 · #182538 · protein
Single particle cryo-EM structure of the chaetomium thermophilum NUP192-NIC96-NUP53-NUP145N complex (NUP192 residues 1-1756; NIC96 residues 240-301; NUP53 31-67; NUP145N 616-683)
7MVV · Nucleoporin NUP192: “Single particle cryo-EM structure of the chaetomium thermophilum NUP192-NIC96-NUP53-NUP145N complex (NUP192…”. Electron microscopy, 20 pockets (best druggability 0.79). MolNFT v1 #182538 on GenesisL1: 3D…
- PDB
- 7MVV
- Type
- protein
- Length
- 1,609 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoporin NUP192; Nucleoporin NIC96; Nucleoporin NUP53; Nucleoporin NUP145N
- UniProt
- G0S4T0, G0S024, G0S156, G0SAK3
- Pockets
- 20 · best druggability 0.79
Structure
electron microscopy · 4 distinct chains · 67% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleoporin NUP192 | protein | 1542 | 67% helix, 1% strand | G0S4T0 |
| B | Nucleoporin NIC96 | protein | 56 | 80% helix, 0% strand | G0S024 |
| D | Nucleoporin NUP53 | protein | 2 | 0% helix, 0% strand | G0S156 |
| C | Nucleoporin NUP145N | protein | 9 | 0% helix, 0% strand | G0SAK3 |
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 294 | 0.79 | 0.90 | 50 | empty |
| 2 | 108 | 0.79 | 0.97 | 25 | empty |
| 3 | 713 | 0.77 | 0.82 | 88 | empty |
| 4 | 194 | 0.74 | 0.89 | 32 | empty |
| 5 | 94 | 0.72 | 0.94 | 24 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1625 Ų buried · 2 hydrogen bonds · protein-protein
- A–C · 450 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 222 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 7MVV · Single particle cryo-EM structure of the Chaetomium thermophilum… · the same entry in another collection · chain A against A, TM-score 1.00
- G0S4T0 · AlphaFold monomer V2.0 prediction for nucleoporin NUP192 (G0S4T0) · a predicted model of the same protein · chain A against A, TM-score 0.88
- G0S024 · AlphaFold monomer V2.0 prediction for nucleoporin NIC96 (G0S024) · a predicted model of the same protein · chain B against A, TM-score 0.63
- G0SAK3 · AlphaFold monomer V2.0 prediction for nucleoporin NUP145 (G0SAK3) · a predicted model of the same protein · chain C against A, TM-score 0.40
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0S4T0
- Every structure of UniProt G0S024
- Every structure of UniProt G0S156
- Every structure of UniProt G0SAK3
- Elsewhere: RCSB PDB 7MVV · PDBe 7MVV · UniProt G0S4T0 · UniProt G0S024 · UniProt G0S156 · UniProt G0SAK3
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.