MolNFT v1 · #182488 · protein
Structure of eed bound to eedi-6068
7MSD · Polycomb protein eed: “Structure of eed bound to eedi-6068”. X-ray diffraction, 1 ligand (ZMY), 3 pockets (best druggability 0.78). MolNFT v1 #182488 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7MSD
- Type
- protein
- Length
- 359 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polycomb protein eed
- UniProt
- O75530
- Ligands
- ZMY
- Pockets
- 3 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 6% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Polycomb protein eed | protein | 359 | 6% helix, 47% strand | O75530 |
Ligands and binding sites
- ZMY · (9aP,12aR)-4-(2,2-difluoropropyl)-12-{[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]amino}-7-(trifluoromethyl)-4,5-dihydro-3H-2,4,8,11,12a-pentaazabenzo[4,5]cycloocta[1,2,3-cd]inden-3-one · ligand · chains A
- FMT · Formic acid · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 487 | 0.78 | 0.85 | 39 | empty |
| 2 | 76 | 0.58 | 0.88 | 10 | ZMY |
| 3 | 67 | 0.34 | 0.76 | 16 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75530
- Elsewhere: RCSB PDB 7MSD · PDBe 7MSD · UniProt O75530
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