MolNFT v1 · #182445 · protein
Cryo-EM structure of recbcd with undocked recbnuc and flexible recd C- terminus
7MR1 · Recbcd enzyme subunit recb: “Cryo-EM structure of recbcd with undocked recbnuc and flexible recd C- terminus”. Electron microscopy, 20 pockets (best druggability 0.83). MolNFT v1 #182445 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7MR1
- Type
- protein
- Length
- 2,316 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Recbcd enzyme subunit recb; Recbcd enzyme subunit recc; Recbcd enzyme subunit recd
- EC
- 3.1.11.5
- UniProt
- P08394, P07648, P04993
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 3 distinct chains · 48% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Recbcd enzyme subunit recb (EC 3.1.11.5) | protein | 858 | 48% helix, 9% strand | P08394 |
| C | Recbcd enzyme subunit recc (EC 3.1.11.5) | protein | 1101 | 47% helix, 10% strand | P07648 |
| D | Recbcd enzyme subunit recd (EC 3.1.11.5) | protein | 357 | 49% helix, 10% strand | P04993 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 999 | 0.83 | 0.84 | 98 | empty |
| 2 | 152 | 0.78 | 0.94 | 39 | empty |
| 3 | 973 | 0.77 | 0.79 | 104 | empty |
| 4 | 483 | 0.76 | 0.84 | 56 | empty |
| 5 | 757 | 0.74 | 0.79 | 82 | empty |
Interfaces
2 interfaces between chains.
- B–C · 4835 Ų buried · 42 hydrogen bonds · protein-protein
- C–D · 1428 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 7MR1 · Cryo-EM structure of RecBCD with undocked RecBNuc and flexible RecD C-terminus · the same entry in another collection · chain B against B, TM-score 1.00
- P04993 · AlphaFold monomer V2.0 prediction for recbcd enzyme subunit recd (P04993) · a predicted model of the same protein · chain D against A, TM-score 0.93
- P08394 · AlphaFold monomer V2.0 prediction for recbcd enzyme subunit recb (P08394) · a predicted model of the same protein · chain B against A, TM-score 0.91
- P07648 · AlphaFold monomer V2.0 prediction for recbcd enzyme subunit recc (P07648) · a predicted model of the same protein · chain C against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08394
- Every structure of UniProt P07648
- Every structure of UniProt P04993
- Elsewhere: RCSB PDB 7MR1 · PDBe 7MR1 · UniProt P08394 · UniProt P07648 · UniProt P04993
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