MolNFT v1 · #182428 · protein

DHR1 helicase core

7MQJ · Probable ATP-dependent RNA helicase DHR1: “DHR1 helicase core”. X-ray diffraction, 2 ligands (ADP, MG), 9 pockets (best druggability 0.84). MolNFT v1 #182428 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7MQJ
Type: protein
Length: 773 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable ATP-dependent RNA helicase DHR1
EC: 3.6.4.13
UniProt: Q04217
Ligands: ADP, MG
Pockets: 9 · best druggability 0.84

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Probable ATP-dependent RNA helicase DHR1 (EC 3.6.4.13)	protein	773	42% helix, 15% strand	Q04217

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	998	0.84	0.85	116	empty
2	398	0.69	0.81	49	empty
3	356	0.66	0.80	34	MG, ADP
4	246	0.53	0.76	29	empty
5	79	0.38	0.77	13	empty

Compared structures

7MQJ · Dhr1 Helicase Core · the same entry in another collection · chain A against A, TM-score 1.00
Q04217 · AlphaFold monomer V2.0 prediction for probable ATP-dependent RNA helicase DHR1 (Q04217) · a predicted model of the same protein · chain A against A, TM-score 0.69

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q04217
Elsewhere: RCSB PDB 7MQJ · PDBe 7MQJ · UniProt Q04217

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