UniProt Q04217
Probable ATP-dependent RNA helicase DHR1 (Q04217)
Probable ATP-dependent RNA helicase DHR1 (UniProt Q04217), EC 3.6.4.13: 11 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 18 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q04217
- Protein
- Probable ATP-dependent RNA helicase DHR1
- EC
- 3.6.4.13
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 18 · 7 records with a druggable one
Structures
12 records of Q04217 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6H57 | Crystal structure of S. cerevisiae deah-box RNA helicase DHR1, essential for small ribosomal… | x-ray diffraction | A | MG, CL | — |
| 6ZQD | Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Post-A1 | electron microscopy | JD | — | 1 (best 0.85) |
| 6ZQE | Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Dis-A (Poly-Ala) | electron microscopy | JD | — | 1 (best 0.85) |
| 6ZQF | Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Dis-B (Poly-Ala) | electron microscopy | JD | — | 2 (best 0.84) |
| 6ZQG | Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Dis-C | electron microscopy | JD | — | 2 (best 0.85) |
| 7AJU | Cryo-EM structure of the 90S-exosome super-complex (state Post-A1-exosome) | electron microscopy | JD | — | 2 (best 0.86) |
| 7D4I | Cryo-EM structure of 90S small ribosomal precursors complex with the DEAH-box RNA helicase Dhr1… | electron microscopy | RZ | ADP | — |
| 7D5T | Cryo-EM structure of 90S preribosome with inactive Utp24 (state F1) | electron microscopy | RZ | ADP | 1 (best 0.86) |
| 7D63 | Cryo-EM structure of 90S preribosome with inactive Utp24 (state C) | electron microscopy | RZ | ADP | — |
| 7MQJ | Dhr1 Helicase Core | x-ray diffraction | A | MG, ADP | 9 (best 0.84) |
| 7MQJ | DHR1 helicase core | x-ray diffraction | A | MG, ADP | — |
| Q04217 | AlphaFold monomer V2.0 prediction for probable ATP-dependent RNA helicase DHR1 (Q04217) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6H57 chain A against the predicted model Q04217: TM-score 0.82, RMSD 4.75 Å
- 6ZQG chain JD against the predicted model Q04217: TM-score 0.80, RMSD 4.01 Å
- 7MQJ chain A against the predicted model Q04217: TM-score 0.69, RMSD 4.93 Å
- 7MQJ chain A against the predicted model Q04217: TM-score 0.69, RMSD 4.93 Å
- 7D63 chain RZ against the predicted model Q04217: TM-score 0.67, RMSD 5.60 Å
- 7D4I chain RZ against the predicted model Q04217: TM-score 0.67, RMSD 5.54 Å
- 7D5T chain RZ against the predicted model Q04217: TM-score 0.67, RMSD 5.54 Å
- 6ZQD chain JD against the predicted model Q04217: TM-score 0.62, RMSD 5.72 Å
- 7AJU chain JD against the predicted model Q04217: TM-score 0.62, RMSD 5.75 Å
- 6ZQE chain JD against the predicted model Q04217: TM-score 0.62, RMSD 5.65 Å
Elsewhere
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