MolNFT v1 · #182396 · protein

GRB2 SH2 domain with compound 7

7MPH: “GRB2 SH2 domain with compound 7”. X-ray diffraction, 2 ligands (ZLY, SO4). MolNFT v1 #182396 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7MPH
Type: protein
Length: 563 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P62993
Ligands: ZLY, SO4

Structure

x-ray diffraction · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	90	—	P62993
B	—	protein	94	—	P62993
C, D, E	—	protein	95	—	P62993
F	—	protein	94	—	P62993

Ligands and binding sites

ZLY · (4-{(10R,11E,14S,18S)-18-(2-amino-2-oxoethyl)-14-[(naphthalen-1-yl)methyl]-8,17,20-trioxo-7,16,19-triazaspiro[5.14]icos-11-en-10-yl}phenyl)acetic acid · ligand · 6 copies · chains A, B, C, D, E, F
SO4 · Sulfate ion · ion · 11 copies · chains A, E, B, C, D, F
EDO · 1,2-ethanediol · additive · 13 copies · chains A, B, C, D, E, F

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7MPH · GRB2 SH2 Domain with Compound 7 · the same entry in another collection · chain F against F, TM-score 1.00
P62993 · AlphaFold monomer V2.0 prediction for growth factor receptor-bound protein 2 (P62993) · a predicted model of the same protein · chain B against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P62993
Elsewhere: RCSB PDB 7MPH · PDBe 7MPH · UniProt P62993

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