MolNFT v1 · #182387 · protein

Crystal structure of the cytosolic domain of tribolium castaneum PINK1 in the non-phosphorylated state

7MP8 · SERINE/THREONINE-protein kinase PINK1, mitochondrial-like…: “Crystal structure of the cytosolic domain of tribolium castaneum PINK1 in the non-phosphorylated state”. X-ray diffraction, 1 ligand (SO4), 5 pockets (best druggability…

PDB: 7MP8
Type: protein
Length: 399 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase PINK1, mitochondrial-like protein
UniProt: D6WMX4
Ligands: SO4
Pockets: 5 · best druggability 0.63

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase PINK1, mitochondrial-like protein	protein	399	44% helix, 16% strand	D6WMX4

Ligands and binding sites

SO4 · Sulfate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	267	0.63	0.80	26	empty
2	203	0.59	0.81	40	empty
3	212	0.52	0.76	26	empty
4	112	0.44	0.78	16	empty
5	77	0.34	0.76	17	empty

Compared structures

7MP8 · Crystal structure of the cytosolic domain of Tribolium castaneum PINK1 in the… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt D6WMX4
Elsewhere: RCSB PDB 7MP8 · PDBe 7MP8 · UniProt D6WMX4

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