MolNFT v1 · #182384 · protein
Autoinhibited neurofibrobmin
7MP5 · Isoform I of neurofibromin: “Autoinhibited neurofibrobmin”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #182384 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7MP5
- Type
- protein
- Length
- 2,302 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform I of neurofibromin
- UniProt
- P21359
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 2 distinct chains · 72% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isoform I of neurofibromin | protein | 1629 | 69% helix, 5% strand | P21359 |
| B | Isoform I of neurofibromin | protein | 673 | 77% helix, 0% strand | P21359 |
Pockets
20 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1191 | 0.82 | 0.83 | 86 | empty |
| 2 | 105 | 0.65 | 0.89 | 21 | empty |
| 3 | 653 | 0.64 | 0.74 | 64 | empty |
| 4 | 482 | 0.61 | 0.75 | 55 | empty |
| 5 | 195 | 0.55 | 0.79 | 28 | empty |
Interfaces
1 interface between chains.
- A–B · 3285 Ų buried · 31 hydrogen bonds · protein-protein
Compared structures
- 7MP5 · Autoinhibited neurofibrobmin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21359
- Elsewhere: RCSB PDB 7MP5 · PDBe 7MP5 · UniProt P21359
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