MolNFT v1 · #182315 · protein
PTP1B F225Y in complex with TCS401
7MN7 · Tyrosine-protein phosphatase non-receptor type 1: “PTP1B F225Y in complex with TCS401”. X-ray diffraction, 2 ligands (OTA, CL). MolNFT v1 #182315 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7MN7
- Type
- protein
- Length
- 300 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase non-receptor type 1
- EC
- 3.1.3.48
- UniProt
- P18031
- Ligands
- OTA, CL
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) | protein | 300 | 39% helix, 21% strand | P18031 |
Ligands and binding sites
- OTA · 2-(oxalyl-amino)-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-3-carboxylic acid · ligand · chains A
- CL · Chloride ion · ion · 3 copies · chains A
- GOL · Glycerol · additive · 4 copies · chains A
- TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7MN7 · PTP1B F225Y in complex with TCS401 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18031
- Elsewhere: RCSB PDB 7MN7 · PDBe 7MN7 · UniProt P18031
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