MolNFT v1 · #182167 · protein

Mouse CTPS2 bound to inhibitor R80

7MIU: “Mouse CTPS2 bound to inhibitor R80”. Electron microscopy, 3 ligands (ZG4, UTP, MG). MolNFT v1 #182167 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7MIU
Type: protein
Length: 2,172 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P70303
Ligands: ZG4, UTP, MG

Structure

electron microscopy · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
D, C, H, G	—	protein	543	—	P70303

Ligands and binding sites

ZG4 · N-(1-{2-[(cyclopropanesulfonyl)amino]-1,3-thiazol-4-yl}cyclopropyl)-5-(6-ethoxypyrazin-2-yl)pyridine-2-carboxamide · ligand · 4 copies · chains D, C, H, G
UTP · Uridine 5'-triphosphate · ligand · 4 copies · chains D, C, G, H
MG · Magnesium ion · metal · 4 copies · chains D, C, H, G

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7MIU · Mouse CTPS2 bound to inhibitor R80 · the same entry in another collection · chain D against D, TM-score 1.00
P70303 · AlphaFold monomer V2.0 prediction for CTP synthase 2 (P70303) · a predicted model of the same protein · chain D against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P70303
Elsewhere: RCSB PDB 7MIU · PDBe 7MIU · UniProt P70303

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