MolNFT v1 · #182051 · protein

Crystal structure of CSF1R in complex with vimseltinib

7MFC · Macrophage colony-stimulating factor 1 receptor: “Crystal structure of CSF1R in complex with vimseltinib”. X-ray diffraction, 1 ligand (Z6V), 1 pocket (best druggability 0.71). MolNFT v1 #182051 on GenesisL1: 3D structure, binding…

PDB: 7MFC
Type: protein
Length: 287 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Macrophage colony-stimulating factor 1 receptor
EC: 2.7.10.1
UniProt: P07333
Ligands: Z6V
Pockets: 1 · best druggability 0.71

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Macrophage colony-stimulating factor 1 receptor (EC 2.7.10.1)	protein	287	43% helix, 18% strand	P07333

Ligands and binding sites

Z6V · Vimseltinib · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	509	0.71	0.80	54	Z6V

Compared structures

7MFC · Crystal structure of CSF1R in complex with vimseltinib · the same entry in another collection · chain A against A, TM-score 1.00
P07333 · AlphaFold monomer V2.0 prediction for macrophage colony-stimulating factor 1 receptor… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07333
Elsewhere: RCSB PDB 7MFC · PDBe 7MFC · UniProt P07333

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