MolNFT v1 · #181982 · protein

Human APEX/REF1 homodimer formed under oxidative condition

7MCR · DNA-(apurinic or apyrimidinic site) endonuclease…: “Human APEX/REF1 homodimer formed under oxidative condition”. X-ray diffraction, 1 ligand (MG), 2 pockets (best druggability 0.40). MolNFT v1 #181982 on GenesisL1: 3D structure…

PDB: 7MCR
Type: protein
Length: 275 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA-(apurinic or apyrimidinic site) endonuclease, mitochondrial
UniProt: P27695
Ligands: MG
Pockets: 2 · best druggability 0.40

Structure

x-ray diffraction · 1 distinct chain · 29% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA-(apurinic or apyrimidinic site) endonuclease, mitochondrial	protein	275	29% helix, 26% strand	P27695

Ligands and binding sites

MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	124	0.40	0.75	20	empty
2	56	0.33	0.77	14	empty

Compared structures

7MCR · Human Apex/Ref1 homodimer formed under oxidative condition · the same entry in another collection · chain A against A, TM-score 1.00
P27695 · AlphaFold monomer V2.0 prediction for DNA-(apurinic or apyrimidinic site) endonuclease… · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P27695
Elsewhere: RCSB PDB 7MCR · PDBe 7MCR · UniProt P27695

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