MolNFT v1 · #181942 · protein

N-terminal domain of mouse surfactant protein B, 6W mutant

7MBK · Pulmonary surfactant-associated protein B: “N-terminal domain of mouse surfactant protein B, 6W mutant”. X-ray diffraction, 1 pocket (best druggability 0.88). MolNFT v1 #181942 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 7MBK
Type: protein
Length: 159 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pulmonary surfactant-associated protein B
UniProt: P50405
Pockets: 1 · best druggability 0.88

Structure

x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Pulmonary surfactant-associated protein B	protein	82	71% helix, 0% strand	P50405
A	Pulmonary surfactant-associated protein B	protein	77	75% helix, 0% strand	P50405

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	555	0.88	0.93	44	empty

Interfaces

1 interface between chains.

B–A · 1793 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

7MBK · N-terminal domain of mouse surfactant protein B, 6W mutant · the same entry in another collection · chain B against B, TM-score 1.00
P50405 · AlphaFold monomer V2.0 prediction for pulmonary surfactant-associated protein B (P50405) · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P50405
Elsewhere: RCSB PDB 7MBK · PDBe 7MBK · UniProt P50405

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.