MolNFT v1 · #181794 · protein

E1435Q YCF1 mutant in inward-facing wide conformation

7M69 · Metal resistance protein YCF1: “E1435Q YCF1 mutant in inward-facing wide conformation”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #181794 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7M69
Type: protein
Length: 1,390 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Metal resistance protein YCF1
EC: 7.2.2.2, 7.6.2.3
UniProt: P39109
Pockets: 20 · best druggability 0.84

Structure

electron microscopy · 1 distinct chain · 64% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Metal resistance protein YCF1 (EC 7.2.2.2, 7.6.2.3)	protein	1390	64% helix, 7% strand	P39109

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1193	0.84	0.85	90	empty
2	286	0.75	0.87	48	empty
3	67	0.73	0.97	21	empty
4	85	0.71	0.94	17	empty
5	401	0.71	0.81	46	empty

Modifications

Observed in the structure: 3 modified, 1 disulfide (phosphorylation, disulfide).

Compared structures

7M69 · E1435Q Ycf1 mutant in inward-facing wide conformation · the same entry in another collection · chain A against A, TM-score 1.00
P39109 · AlphaFold monomer V2.0 prediction for metal resistance protein YCF1 (P39109) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P39109
Elsewhere: RCSB PDB 7M69 · PDBe 7M69 · UniProt P39109

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