MolNFT v1 · #181451 · protein

Cholera toxin B subunit with attached SIV epitope

7LVB · Cholera enterotoxin B-SUBUNIT,SURFACE protein GP120: “Cholera toxin B subunit with attached SIV epitope”. X-ray diffraction, 2 ligands (GAL, CL), 14 pockets (best druggability 0.76). MolNFT v1 #181451 on GenesisL1: 3D structure…

PDB: 7LVB
Type: protein
Length: 1,073 residues
Chains: 10
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cholera enterotoxin B-SUBUNIT,SURFACE protein GP120
UniProt: Q57193
Ligands: GAL, CL
Pockets: 14 · best druggability 0.76

Structure

x-ray diffraction · 2 distinct chains · 24% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
D, E, G, H, C, I, J	Cholera enterotoxin B-SUBUNIT,SURFACE protein GP120	protein	107	23% helix, 34% strand	Q57193
F, A, B	Cholera enterotoxin B-SUBUNIT,SURFACE protein GP120	protein	108	24% helix, 33% strand	Q57193

Ligands and binding sites

GAL · beta-D-galactopyranose · sugar · 10 copies · chains D, E, F, G, H, A, B, C, I, J
CL · Chloride ion · ion · 11 copies · chains D, E, G, F, H, A, B, C, I, J
PGE · Triethylene glycol · additive · 15 copies · chains D, E, H, F, G, A, B, C, I, J

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

14 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	941	0.76	0.79	38	empty
2	1079	0.74	0.77	44	empty
3	55	0.43	0.83	18	empty
4	63	0.41	0.81	20	empty
5	58	0.40	0.81	20	empty

Interfaces

10 interfaces between chains.

E–F · 1387 Å² buried · 24 hydrogen bonds · protein-protein
D–H · 1384 Å² buried · 24 hydrogen bonds · protein-protein
F–G · 1382 Å² buried · 25 hydrogen bonds · protein-protein
A–J · 1379 Å² buried · 24 hydrogen bonds · protein-protein
G–H · 1372 Å² buried · 23 hydrogen bonds · protein-protein

Compared structures

7LVB · Cholera toxin B subunit with attached SIV epitope · the same entry in another collection · chain D against D, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q57193
Elsewhere: RCSB PDB 7LVB · PDBe 7LVB · UniProt Q57193

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.