MolNFT v1 · #181430 · protein

N-terminus of SKP2 bound to cyclin a

7LUO · S-phase kinase-associated protein 2,CYCLIN-A2: “N-terminus of SKP2 bound to cyclin a”. X-ray diffraction, 3 pockets (best druggability 0.77). MolNFT v1 #181430 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7LUO
Type: protein
Length: 549 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: S-phase kinase-associated protein 2,CYCLIN-A2; SKP2 motif 1 uncharacterized fragment 1…
UniProt: P20248
Pockets: 3 · best druggability 0.77

Structure

x-ray diffraction · 3 distinct chains · 56% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	S-phase kinase-associated protein 2,CYCLIN-A2	protein	267	60% helix, 0% strand	P20248
B	SKP2 motif 1 uncharacterized fragment 1	protein	8	0% helix, 0% strand	—
D	SKP2 motif 1 uncharacterized fragment 2	protein	7	0% helix, 0% strand	—

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	139	0.77	0.95	28	empty
2	142	0.75	0.94	27	empty
3	69	0.28	0.72	13	empty

Compared structures

7LUO · N-terminus of Skp2 bound to Cyclin A · the same entry in another collection · chain A against A, TM-score 1.00
P20248 · AlphaFold monomer V2.0 prediction for cyclin-A2 (P20248) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P20248
Elsewhere: RCSB PDB 7LUO · PDBe 7LUO · UniProt P20248

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