MolNFT v1 · #181356 · protein
Crystal structure of the human neutralizing antibody Fab fragment T025 bound to tbev ediii (siberian subtype)
7LSG · T025 Fab heavy chain: “Crystal structure of the human neutralizing antibody Fab fragment T025 bound to tbev ediii (siberian subtype)”. X-ray diffraction, 2 pockets (best druggability 0.61). MolNFT v1 #181356 on GenesisL1: 3D…
- PDB
- 7LSG
- Type
- protein
- Length
- 522 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- T025 Fab heavy chain; T025 Fab light chain; Core protein
- EC
- 3.4.21.91, 3.6.1.15, 3.6.4.13
- UniProt
- G8FGD9
- Pockets
- 2 · best druggability 0.61
Structure
x-ray diffraction · 3 distinct chains · 6% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | T025 Fab heavy chain | protein | 216 | 8% helix, 50% strand | — |
| L | T025 Fab light chain | protein | 212 | 6% helix, 50% strand | — |
| C | Core protein (EC 3.4.21.91, 3.6.1.15, 3.6.4.13) | protein | 94 | 0% helix, 57% strand | G8FGD9 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 531 | 0.61 | 0.74 | 65 | empty |
| 2 | 94 | 0.34 | 0.74 | 25 | empty |
Interfaces
3 interfaces between chains.
- H–L · 1740 Ų buried · 13 hydrogen bonds · protein-protein
- H–C · 388 Ų buried · 10 hydrogen bonds · protein-protein
- L–C · 304 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 7LSG · Crystal structure of the human neutralizing antibody Fab fragment T025 bound to TBEV… · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G8FGD9
- Elsewhere: RCSB PDB 7LSG · PDBe 7LSG · UniProt G8FGD9
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