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Crystal structure of the human neutralizing antibody Fab fragment T025 bound to tbev ediii (siberian subtype)
Analyse Crystal structure of the human neutralizing antibody Fab fragment T025 bound to… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7LSG
- Type
- protein
- Length
- 522 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- T025 Fab heavy chain; T025 Fab light chain; Core protein
- EC
- 3.4.21.91, 3.6.1.15, 3.6.4.13
- UniProt
- G8FGD9
- Pockets
- 2 · best druggability 0.61
Structure
x-ray diffraction · 3 distinct chains · 6% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | T025 Fab heavy chain | protein | 216 | 8% helix, 50% strand | — |
| L | T025 Fab light chain | protein | 212 | 6% helix, 50% strand | — |
| C | Core protein (EC 3.4.21.91, 3.6.1.15, 3.6.4.13) | protein | 94 | 0% helix, 57% strand | G8FGD9 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 531 | 0.61 | 0.74 | 65 | empty |
| 2 | 94 | 0.34 | 0.74 | 25 | empty |
Interfaces
3 interfaces between chains.
- H–L · 1740 Ų buried · 13 hydrogen bonds · protein-protein
- H–C · 388 Ų buried · 10 hydrogen bonds · protein-protein
- L–C · 304 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 7LSG · Crystal structure of the human neutralizing antibody Fab fragment T025 bound to TBEV… · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G8FGD9
- Elsewhere: RCSB PDB 7LSG · PDBe 7LSG · UniProt G8FGD9
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