Structural basis for specific binding of polycomb chromodomain to histone H3 methylated at K27

Structure

x-ray diffraction · 2 distinct chains · 20% helix, 47% strand (DSSP).

Ligands and binding sites

• CL · Chloride ion · ion · 2 copies · chains A
• BME · Beta-mercaptoethanol · additive · chains A
• ACY · Acetic acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 753 Ų buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (methylation).

Compared structures

• 1PFB · Structural Basis for specific binding of polycomb chromodomain to histone H3 methylated… · the same entry in another collection · chain A against A, TM-score 1.00
• P26017 · AlphaFold monomer V2.0 prediction for polycomb group protein pc (P26017) · a predicted model of the same protein · chain A against A, TM-score 0.91
• P06352 · AlphaFold monomer V2.0 prediction for histone H3, embryonic (P06352) · a predicted model of the same protein · chain B against A, TM-score 0.35

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P26017
• Every structure of UniProt P06352
• Elsewhere: RCSB PDB 1PFB · PDBe 1PFB · UniProt P26017 · UniProt P06352