Tna modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')PPP(5')G

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• TG · 2-azanyl-9-[(2~{R},3~{R},4~{S})-3-oxidanyl-4-[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxy-oxolan-2-yl]-1~{H}-purin-6-one · ligand · 2 copies · chains A, B
• GP3 · Diguanosine-5'-triphosphate · ligand · 2 copies · chains A, B
• LCG · [(1R,3R,4R,7S)-7-hydroxy-3-(guanin-9-yl)-2,5-dioxabicyclo[2.2.1]hept-1-yl]methyl dihydrogen phosphate · ligand · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 557 Ų buried · 45 hydrogen bonds · nucleic-nucleic

Modifications

Observed in the structure: 7 modified, 4 covalent (nucleotide modification, covalent ligand).

Compared structures

• 7LNG · TNA modification at 3' end of RNA primer complex with guanosine dinucleotide ligand… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Elsewhere: RCSB PDB 7LNG · PDBe 7LNG