MolNFT v1 · #181033 · protein
The structure of the insect olfactory receptor OR5 from machilis hrabei in complex with eugenol
7LID · MHOR5: “The structure of the insect olfactory receptor OR5 from machilis hrabei in complex with eugenol”. Electron microscopy, 1 ligand (EOL), 20 pockets (best druggability 0.77). MolNFT v1 #181033 on GenesisL1: 3D structure…
- PDB
- 7LID
- Type
- protein
- Length
- 1,524 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MHOR5
- Ligands
- EOL
- Pockets
- 20 · best druggability 0.77
Structure
electron microscopy · 1 distinct chain · 77% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | MHOR5 | protein | 381 | 77% helix, 1% strand | — |
Ligands and binding sites
- EOL · 2-methoxy-4-(prop-2-en-1-yl)phenol · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 86 | 0.77 | 0.98 | 15 | EOL |
| 2 | 86 | 0.76 | 0.98 | 15 | EOL |
| 3 | 85 | 0.76 | 0.97 | 15 | EOL |
| 4 | 82 | 0.76 | 0.98 | 15 | EOL |
| 5 | 1188 | 0.74 | 0.77 | 79 | empty |
Interfaces
4 interfaces between chains.
- B–C · 1286 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 1259 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 1257 Ų buried · 12 hydrogen bonds · protein-protein
- A–D · 1257 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 7LID · The structure of the insect olfactory receptor OR5 from Machilis hrabei in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7LID · PDBe 7LID
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