Research workbench
The structure of the insect olfactory receptor OR5 from machilis hrabei in complex with eugenol
Analyse The structure of the insect olfactory receptor OR5 from machilis hrabei in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7LID
- Type
- protein
- Length
- 1,524 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MHOR5
- Ligands
- EOL
- Pockets
- 20 · best druggability 0.77
Structure
electron microscopy · 1 distinct chain · 77% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | MHOR5 | protein | 381 | 77% helix, 1% strand | — |
Ligands and binding sites
- EOL · 2-methoxy-4-(prop-2-en-1-yl)phenol · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 86 | 0.77 | 0.98 | 15 | EOL |
| 2 | 86 | 0.76 | 0.98 | 15 | EOL |
| 3 | 85 | 0.76 | 0.97 | 15 | EOL |
| 4 | 82 | 0.76 | 0.98 | 15 | EOL |
| 5 | 1188 | 0.74 | 0.77 | 79 | empty |
Interfaces
4 interfaces between chains.
- B–C · 1286 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 1259 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 1257 Ų buried · 12 hydrogen bonds · protein-protein
- A–D · 1257 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 7LID · The structure of the insect olfactory receptor OR5 from Machilis hrabei in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7LID · PDBe 7LID
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