MolNFT v1 · #181015 · protein
Structure of arabidopsis thaliana sulfate transporter ATSULTR4;1
7LHV · Sulfate transporter 4.1, chloroplastic: “Structure of arabidopsis thaliana sulfate transporter ATSULTR4;1”. Electron microscopy, 3 ligands (S1P, LBN, SO4), 17 pockets (best druggability 0.77). MolNFT v1 #181015 on GenesisL1: 3D…
- PDB
- 7LHV
- Type
- protein
- Length
- 1,150 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sulfate transporter 4.1, chloroplastic
- UniProt
- Q9FY46
- Ligands
- S1P, LBN, SO4
- Pockets
- 17 · best druggability 0.77
Structure
electron microscopy · 1 distinct chain · 65% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Sulfate transporter 4.1, chloroplastic | protein | 575 | 65% helix, 6% strand | Q9FY46 |
Ligands and binding sites
- S1P · (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate · ligand · 4 copies · chains A, B
- LBN · 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine · ligand · 2 copies · chains A, B
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
17 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 788 | 0.77 | 0.81 | 70 | SO4 |
| 2 | 741 | 0.76 | 0.81 | 64 | SO4 |
| 3 | 159 | 0.68 | 0.88 | 26 | empty |
| 4 | 615 | 0.64 | 0.75 | 57 | empty |
| 5 | 272 | 0.64 | 0.80 | 38 | S1P |
Interfaces
1 interface between chains.
- A–B · 2532 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 7LHV · Structure of Arabidopsis thaliana sulfate transporter AtSULTR4;1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9FY46 · AlphaFold monomer V2.0 prediction for sulfate transporter 4.1, chloroplastic (Q9FY46) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9FY46
- Elsewhere: RCSB PDB 7LHV · PDBe 7LHV · UniProt Q9FY46
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